The two most widely used TBS patterns are:
Continuous (cTBS) stimulation. Here, a 40 second train of uninterrupted TBS is given on the right dorsolateral prefrontal cortex and typically 600 pulses.
lntermittent stimulation (iTBS). Here, 2 seconds of stimulation on the left dorsolateral prefrontal cortex is followed by an 8 second pause, for example for a total of 190 seconds and typically 600 pulses.
In August 2018, FDA cleared a 3-minute TBS protocol for treatment of major depressive disorder. The FDA cleared protocol was based on a clinical study - the THREE-D trial - which was led in partnership by three leading research hospitals in Canada (CAMH, UHN, and UBC). The THREE-D trial is the largest, double-blinded, randomized TMS trial to date involving 414 participants suffering from major depressive disorder. The article was published in The Lancet in 2018.